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Selleckchem

主营：分子类，蛋白类，抗体类，生化类试剂

℡ 4000-520-616

产品名称：Selleck Chemicals/UNC2025/S9662

产品编号：S9662

市场价：¥7140.00

场地：美国(厂家直采)

产品分类：蛋白类>多肽>多肽合成>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$357.00

品牌： Selleck Chemicals

公司：Selleckchem

公司分类：

商品介绍

Description

UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. UNC2025 also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, Kit (c-Kit) and Met (c-Met) with IC50 of 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM, 8.18 nM and 364 nM, respectively.

Targets

FLT3 ^[1](Cell-free assay)	Mer ^[1](Cell-free assay)	Axl ^[1](Cell-free assay)	TrkA ^[1](Cell-free assay)	TrkC ^[1](Cell-free assay)	View More
0.35 nM	0.46 nM	1.65 nM	1.67 nM	4.38 nM	View More

In vitro

Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.^[1]

In vivo

UNC2025 is a potent and highly orally bioavailable Mer inhibitor that is capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow.^[1]

品牌介绍

Selleck Chemicals提供了超过120,000种用于细胞信号通路研究的抑制剂。我们积极跟踪最新科学，因此我们的客户可以依靠我们成为最新抑制剂的领先供应商。

Selleck的生物活性化合物库由8,000多个具有经过验证的生物学和药理活性的小分子组成。这些分子的安全性和有效性已通过临床前和临床研究证明，其中许多是FDA批准的化合物。

公司介绍

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