Selleck Chemicals/Bay 11-7085/S7352,Selleck Chemicals,,Selleckchem,Selleck Chemicals,Selleck,+,,Array.Array蚂蚁淘厂家直采.

产品名称：Selleck Chemicals/Bay 11-7085/S7352

产品编号：S7352

市场价：¥4740.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$237.00

品牌： Selleck Chemicals

公司：Selleckchem

公司分类：

商品介绍

Description

BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.

Features

Selective IκBα phosphorylation inhibitor.

Targets

IκBα phosphorylation ^[1]

10 μM

In vitro

BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. ^[1] BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel. ^[3] Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells. ^[4]

Cell Data

Cell Lines	Assay Type	Incubation Time	Activity Description	PMID
HeLa cells	MoHuSpVv[3Srb36gZZN{[Xl?		MUHJcohq[mm2aX;uJI9nKEmOLUGtZYxxcGFvaX7keYNmCCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBJUyjIHPlcIx{KGG\|c3Xzd4VlKGG\|IHLsc4NscW6pIH;mJJA2OC:yNkWgcpVkdGWjcjD0doFve2yxY3H0bY9vNCCLQ{WwQVAvOSEQvF2=	M4DMNFE4QDR3OEWw
human A2780 cells	M2L0TmZ2dmO2aX;uJIF{e2G7		M1;CWGFvfGm2dX3vdkBi[3Srdnn0fUBi2GrboP0JIh2dWGwIFGyO\|gxKGOnbHzzJINwNWO3bIT1doVlKHerdHigcYV{d3SqZXzpZYwh[2WubDDtc45wdGG7ZYLzJIJ6KG[rcnXmcJkhdHWlaXldoF{SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR\|UxRTJwNjFOwG0>	MUiyNlMzPjN7NR?=
human BxPC3 cells	NXz4NWJrS3m2b4TvfIlkcXS7IHHzd4F6	M{C1SlQhcA>?	M3PQU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJ5WEN\|IHPlcIx{KGOxLXP1cJR2emWmIIfpeIghcHWvYX6gcYV{d3SqZXzpZYwh[2WubIOgZYZ1XJiNDDodpMh[nliZnny[YZtgSCudXPp[oVz[XOnIHHzd4F6KHKnbHH0bZZmKHSxIHPvcpRzd2xuIFXDOVA:Oy53IN88US=>	MkDKNlU2QDF{NkG=
human SKOV3 cells	M3TUTGN6fG:2b4jpZ4l1gSCjc4PhfS=>	M160bVQhcA>?	NFzyR3hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyClbz3jeYx1fXKnZDD3bZRpKGi3bXHuJI1me2:2aHXsbYFtKGOnbHzzJIFnfGW{IESgbJJ{KGK7IHpdoVndHlibIXjbYZmemG\|ZTDhd5NigSC{ZXzheIl3SC2bzDjc451em:uLDDFR\|UxRTVizszN	MWSyOVU5OTJ4MR?=
human SU86 cells	NXH6d25RS3m2b4TvfIlkcXS7IHHzd4F6	MnTpOEBp	NW cGJwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1V6NjDj[YxteyClbz3jeYx1fXKnZDD3bZRpKGi3bXHuJI1me2:2aHXsbYFtKGOnbHzzJIFnfGW{IESgbJJ{KGK7IHpdoVndHlibIXjbYZmemG\|ZTDhd5NigSC{ZXzheIl3SC2bzDjc451em:uLDDFR\|UxRTVwOTFOwG0>	NHPLfWIzPTV6MUK2NS=>
human HT-29 cells	NWXDW2dETnWwY4Tpc44h[XO\|YYm=	NXnKeWM2OzBibXnudy=>	MkHUVoVlfWO2aX;uJI9nKGOnbHz1cIFzKEeVSDDs[ZZmdCCrbjDoeY1idiCKVD2yPUBkWyuczDpcoN2[mG2ZXSg[o9zKDNyIH3pcpMhm:ubH;3[YQh[nliY3:tZ5VtfHW{aX7nJJdqfGhiaIXtZY4hdWW\|b4To[Yxq[WxiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgOUBpenNiYomg[olzW[ueTDseYNqmW{YYPlJIF{e2G7	MWCyOVU5OTJ4MR?=

... Click to View More Cell Line Experimental Data

In vivo

BAY 11-7085 inhibits the meningitis-associated increase in NF-κB activity, and results in an improvement of the clinical status of infected rats and a marked attenuation of meningitis-associated CNS complications and meningeal inflammation. ^[2] BAY 11-7085 increases the efficacy of paclitaxel-induced inhibition of intraabdominal dissemination and production of ascites in athymic nude mice bearing Caov-3 cells. ^[3]

品牌介绍

Selleck Chemicals提供了超过120,000种用于细胞信号通路研究的抑制剂。我们积极跟踪最新科学，因此我们的客户可以依靠我们成为最新抑制剂的领先供应商。

Selleck的生物活性化合物库由8,000多个具有经过验证的生物学和药理活性的小分子组成。这些分子的安全性和有效性已通过临床前和临床研究证明，其中许多是FDA批准的化合物。

公司介绍

产品分类

更多...